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Piperazine derivatives as iron chelators: a potential application in neurobiology
S Abdelsayed1, N T Ha Duong, C Bureau
1Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baıf, 75205 Paris Cedex 13, France
Abstract:
Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.
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