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[Potential Mechanisms Underlying Acupuncture Regulation on Hypertensive Myocardial Hypertrophy and Cardiac Function

Juan-juan Xin, Jun-hong Gao, Feng-yan Lu

    Zhen Ci Yan Jiu = Acupuncture Research
    |October 28, 2015
    PubMed

    Insights

    Acupuncture may help manage hypertensive heart disease by regulating the nervous system and calcium signaling. This review explores novel acupuncture strategies for treating cardiac hypertrophy and dysfunction.

    Area of Science:

    • Cardiovascular Science
    • Integrative Medicine
    • Neuroscience

    Context:

    • Hypertension causes ventricular remodeling, including myocyte hypertrophy and fibrosis, leading to heart failure.
    • Current treatments are insufficient to block this pathological remodeling process.
    • Acupuncture shows potential for cardioprotection by modulating the autonomic nervous system and calcium signaling.

    Purpose:

    • To review studies on acupuncture's effects on hypertensive myocardial hypertrophy.
    • To propose novel treatment strategies involving acupuncture for cardiac dysfunction.
    • To explore mechanisms related to the autonomic nervous system, endocrine system, cytokines, and calcium signaling.

    Summary:

    • Long-standing hypertension induces myocardial hypertrophy and fibrosis, often progressing to heart failure.
    • Acupuncture may counteract sympathetic overactivity via parasympathetic stimulation, lowering blood pressure and protecting the heart.
    • This review examines acupuncture's potential to regulate intracellular calcium signaling and related proteins in myocytes.

    Impact:

    • Provides a framework for understanding acupuncture's role in managing hypertensive heart disease.
    • Suggests novel therapeutic avenues targeting autonomic, endocrine, and calcium signaling pathways.
    • Highlights acupuncture as a potential complementary therapy for preventing heart failure progression.

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