Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

8.9K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
8.9K
Vascular Resistance01:20

Vascular Resistance

13.0K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
13.0K
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

1.6K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.6K
Vascular Spasm01:16

Vascular Spasm

4.8K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
4.8K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

335
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
335
Arteries and Arterioles01:16

Arteries and Arterioles

7.7K
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An extrarenal renin-producing tumor associated with a 3 cm mature cystic teratoma.

JCEM case reports·2026
Same author

Positive peritoneal cytology and recurrence patterns in endometrial cancer according to postoperative recurrence risk classification: a retrospective cohort study.

International journal of clinical oncology·2026
Same author

Tigrin, a venom-derived cysteine-rich secretory protein from Rhabdophis tigrinus, triggers interleukin-8 release from endothelial cells.

Toxicon : official journal of the International Society on Toxinology·2026
Same author

Zinc-dependent prothrombin activator from Rhabdophis tigrinus venom with extended substrate specificity.

Toxicon : official journal of the International Society on Toxinology·2026
Same author

ASO Visual Abstract: Mesenteric Lymph Node Involvement as a Prognostic Factor in Ovarian Cancer: A Study Using a Standardized Detection Method.

Annals of surgical oncology·2025
Same author

Web-Based Video Intervention and Associated Factors for the Uptake of the Catch-Up Human Papillomavirus Vaccination in Japan: Randomized Controlled Trial.

Journal of medical Internet research·2025

Related Experiment Video

Updated: Mar 31, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

22.4K

[Effect of alcohol on vascular function].

Risa Kudo, Katsuya Yuui, Shogo Kasuda

    Nihon Arukoru Yakubutsu Igakkai Zasshi = Japanese Journal of Alcohol Studies & Drug Dependence
    |October 28, 2015
    PubMed
    Summary

    Acute alcohol intake impairs vascular relaxation, increasing contraction and risk of circulatory issues. Chronic light-to-moderate alcohol may lower blood pressure, while heavy use raises it, impacting vascular function.

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology
    • Toxicology

    Context:

    • Vascular function relies on a balance between vasoconstriction and vasorelaxation.
    • Alcohol consumption disrupts this balance, leading to various clinical conditions.
    • Understanding ethanol's impact on vascular responses is crucial for public health.

    Purpose:

    • To review the effects of acute and chronic ethanol consumption on vascular responses.
    • To analyze impacts on vasoconstriction, endothelium-dependent vasorelaxation, and nerve-mediated vasorelaxation.
    • To elucidate mechanisms linking alcohol intake to circulatory disturbances.

    Summary:

    • Acute ethanol administration generally decreases vasorelaxation, promoting vasoconstriction and potentially causing vasospasms or ischemic heart disease.

    More Related Videos

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    1.7K
    Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
    08:41

    Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

    Published on: June 3, 2019

    10.5K

    Related Experiment Videos

    Last Updated: Mar 31, 2026

    Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
    09:26

    Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

    Published on: February 6, 2019

    22.4K
    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    1.7K
    Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
    08:41

    Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

    Published on: June 3, 2019

    10.5K
  • Chronic low-dose ethanol may enhance endothelium-dependent relaxation and potentially lower blood pressure.
  • Chronic high-dose ethanol increases vasoconstriction and may raise blood pressure, contributing to cardiovascular risks.

    • Impact:

    • Provides insights into the dual role of alcohol in cardiovascular health, differentiating between acute and chronic, and low-dose versus high-dose consumption.
    • Highlights the complex effects of ethanol on nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) pathways.
    • Informs clinical understanding of alcohol-related cardiovascular pathologies and potential therapeutic targets.