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Published on: October 31, 2025
Clinical Evaluation and Management of Inflammatory Myopathies
Sameer Chhibber1, Anthony A Amato2
1Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Abstract:
The idiopathic inflammatory myopathies are classified into four distinct subtypes: dermatomyositis, polymyositis, inclusion body myositis, and immunomediated necrotizing myopathy. These subtypes are clinically, histologically, and pathogenically distinct. Dermatomyositis, polymyositis, and necrotizing myopathy generally respond to immunotherapy, whereas inclusion body myositis does not. In this review, the authors focus on the clinical evaluation and management of idiopathic inflammatory myopathies and highlight recent therapeutic studies and the evolving role of myositis-specific antibodies.
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