Study on the correlation between the changes in intra-abdominal pressure and renal functional in the patients with...

To observe the effect on renal function from increased intra-abdominal pressure.

Sixty patients with abdominal compartment syndrome (ACS) were included in this study. Intra-abdominal pressure, mean arterial pressure (MAP) and central venous pressure (CVP) were recorded three times per day at a fixed time. Meanwhile, blood samples were collected for serum creatinine measurement and urine volume per hour was recorded.

The urine volume gradually decreased with the increasing intra-abdominal pressure, from 92. 6 ± 20 ml/h to 27.9 ± 20 ml/h (p < 0. 05), and the serum creatinine increased from 68.4 ± 39.9 mol/L to 249.4 ± 111.5 mol/L (p < 0. 05). The CVP increased from 0.98 ± 0.19 kPa to 1.56 ± 0.31 kPa with the increase or decrease of the MAP. The increase in intra-abdominal pressure was negatively related to the urine volume (r = -0.193, p < 0.05), and positively related to the serum creatinine (r = 0.162, p < 0.05), but not related to the MAP.

The increase of intra-abdominal pressure, was closely related to oliguria and increasing serum creatinine. The use of fluid resuscitation and diuretics had few effects on the recovery of the renal function. When the intra-abdominal pressure had decreased, the urine volume increased, and the serum creatinine decreased.