Advances in understanding and treating premature ejaculation

Theodore R Saitz1, Ege Can Serefoglu2

  • 1Department of Urology, Oregon Health &Science University, 3303 SW Bond Avenue, CH10U, Portland, OR 97239, USA.

Nature Reviews. Urology
|October 28, 2015
PubMed

Insights

Recent advances have improved understanding of premature ejaculation (PE) epidemiology, pathophysiology, and management. Further research is needed for effective clinical diagnosis and treatment of this common sexual disorder.

Area of Science:

  • Urology
  • Sexual Medicine
  • Men's Health

Background:

  • Premature ejaculation (PE) is a common sexual disorder with evolving understanding.
  • Recent years have seen significant advancements in PE research.

Purpose of the Study:

  • To summarize the current understanding of PE.
  • To highlight recent advancements in PE epidemiology, pathophysiology, and management.
  • To identify areas requiring further research.

Main Methods:

  • Literature review of recent studies on premature ejaculation.
  • Synthesis of current knowledge on PE definitions, classification, prevalence, and etiology.
  • Analysis of evolving treatment options for PE.

Main Results:

  • New definitions and classifications for premature ejaculation have been established.
  • Understanding of PE prevalence and etiological factors has advanced.
  • Treatment strategies for PE have evolved, with ongoing research.

Conclusions:

  • Significant progress has been made in understanding premature ejaculation.
  • Further research is crucial for improving clinical diagnosis and treatment efficacy for PE.
  • Continued investigation is necessary to fully address this prevalent sexual disorder.

Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
27.2K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.4K
Psychosexual Stages of Personality: Genital01:23

Psychosexual Stages of Personality: Genital

The genital stage is the final phase of Sigmund Freud's theory of psychosexual development, beginning at puberty, around age 12. During this stage, sexual energy shifts from self-focused interests to external individuals, marking the development of mature adult sexuality. Freud saw this phase as a time of sexual reawakening, with desires directed toward others outside the family. A healthy transition into this stage, according to Freud, signifies the emergence of two key aspects of adult...
2.1K
Psychosexual Theory of Development01:14

Psychosexual Theory of Development

Sigmund Freud's psychosexual theory of development suggests that early childhood experiences significantly shape personality and behavior. Freud proposed that development is discontinuous, occurring in five distinct stages, each defined by a focus on different erogenous zones. He believed that failure to resolve the conflicts specific to each stage successfully could result in fixation, potentially influencing behavior as adults.
The Five Stages of Psychosexual Development
Freud's psychosexual...
3.3K
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
730
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
683