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Translational Regulation

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...

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Updated: Mar 31, 2026

MS2-Affinity Purification Coupled with RNA Sequencing in Gram-Positive Bacteria

MS2-Affinity Purification Coupled with RNA Sequencing in Gram-Positive Bacteria

Published on: February 23, 2021

sRNATarBase 3.0: an updated database for sRNA-target interactions in bacteria.

Jiang Wang¹, Tao Liu¹, Bo Zhao¹

¹Center of Computational Biology, Beijing Institute of Basic Medical Sciences, Haidian district, Beijing 100850, China.

Nucleic Acids Research

|October 28, 2015

Summary

The updated sRNATarBase database now offers 771 bacterial small regulatory RNA (sRNA)-target interactions, including validated mRNA and protein targets. This resource aids in understanding sRNA functions and developing prediction models.

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Area of Science:

Microbiology
Molecular Biology
Bioinformatics

Background:

Bacterial small regulatory RNAs (sRNAs) are crucial regulators of gene expression, influencing mRNA and protein targets.
Identifying sRNA targets is vital for understanding their biological roles, but data remains limited.

Purpose of the Study:

To update and enhance the sRNATarBase database for improved bacterial sRNA functional studies.
To facilitate the development of sRNA target prediction models by providing a comprehensive resource.

Main Methods:

Manual curation of sRNA-target interactions from scientific literature.
Integration of predicted targets from established tools (sRNATarget, sTarPicker).
Inclusion of detailed binding region information and mutation experiment data.

Main Results:

The updated sRNATarBase contains 771 manually curated sRNA-target entries.
Includes 475 validated sRNA-mRNA and 17 validated sRNA-protein interactions.
Features new tools like NCBI sequence viewer, regulatory network visualization, and GO/pathway annotations.

Conclusions:

The enhanced sRNATarBase provides a valuable, comprehensive resource for bacterial sRNA research.
Facilitates deeper investigation into sRNA-mediated gene regulation and functional studies.