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Updated: Mar 31, 2026
Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates
Published on: December 6, 2017
BDB: biopanning data bank
Bifang He1, Guoshi Chai1, Yaocong Duan1
1Center of Bioinformatics (COBI), Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China.
The Biopanning Data Bank (BDB) is an updated resource for combinatorial peptide library biopanning results. It now includes enhanced data and tools, improving its utility for phage display researchers.
Area of Science:
- Biotechnology
- Bioinformatics
- Molecular Biology
Background:
- The Biopanning Data Bank (BDB) is an updated version of the MimoDB database.
- It serves as a central portal for biopanning results from combinatorial peptide libraries.
Purpose of the Study:
- To enhance the BDB database with updated biopanning data and improved functionalities.
- To provide a comprehensive resource for researchers utilizing phage display technology.
Main Methods:
- Data compilation from 1322 peer-reviewed papers, including 2904 biopanning datasets.
- Revisiting stored data to add peptide affinity, measurement methods, and procedures for 2298 peptides.
- Implementation of a new user-friendly web interface, help system, data visualization, and analysis tools.
Main Results:
- BDB now contains 25,786 peptide sequences, 1704 targets, 492 templates, 447 peptide libraries, and 310 crystal structures.
- Detailed affinity and experimental information added for a significant portion of the peptide data.
- Enhanced web interface and integrated analysis tools improve data accessibility and usability.
Conclusions:
- The updated BDB database offers a significantly improved resource for the biopanning and phage display scientific communities.
- The new features are expected to enhance research efficiency and discovery in peptide-target interactions.
- BDB aims to be a major resource for scholars in the field.
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