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[Interferon and bone]

Takeshi Miyamoto1

  • 1Department of Orthopaedic Surgery, Keio University School of Medice, Japan.

Clinical Calcium
|October 28, 2015
PubMed

Interferon(IFN)α, β and γ were identified, and demonstrated played a crucial role in regulating immune system. Expression of IFN α and β are both promoted by viral infection, and these factors have been utilized to treat the patients with hepatitis C. Meanwhile, IFN γ is expressed in activated T cells, such as Th1 cells, and also plays a crucial role in immune system. Beside the immune roles, IFNs were demonstrated to regulate bone homeostasis via osteoclasts, osteoblasts or both. In this review, I will discuss the roles of IFNs in bone system.

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