Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Roles of Del-1 in effects of hyponatremia on muscle and bone in mice.

Bone·2026

Same author

Systemic administration of osteoblast-derived collagenase released extracellular vesicles restores trabecular bone loss in ovariectomized mice.

Bone·2026

Same author

Tmem119 is involved in the bone repair enhanced by parathyroid hormone in female mice.

The Journal of endocrinology·2026

Same author

The role of Tmem119 in the estrogen action on bone in mice.

Journal of bone and mineral metabolism·2025

Same author

Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice.

Aging·2025

Same author

Bone-muscle interactions.

Osteoporosis and sarcopenia·2025

Search research articles

Related Experiment Video

Updated: Mar 31, 2026

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

[Treatment for hepatic osteodystrophy].

¹Department of Physiology and Regenerative Medicine,Kinki University Faculty of Medicine, Japan.

Clinical Calcium

|October 28, 2015

Summary

This summary is machine-generated.

Bisphosphonates and Vitamin D show promise for treating bone density loss in chronic liver disease patients. Estrogen use is limited due to risks of liver dysfunction and cancer.

More Related Videos

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

Related Experiment Videos

Last Updated: Mar 31, 2026

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

Area of Science:

Hepatology and Endocrinology
Bone Metabolism in Liver Disease

Context:

Chronic liver diseases (e.g., cirrhosis) have diverse causes like viral hepatitis and steatohepatitis.
Hepatic osteodystrophy lacks sufficient clinical evidence for effective treatment strategies.
Vitamin D deficiency is common in hepatic osteodystrophy pathogenesis.

Purpose:

To review current evidence on treating hepatic osteodystrophy in chronic liver disease.
To evaluate the efficacy of bisphosphonates and Vitamin D for bone health in these patients.
To discuss the limitations of estrogen therapy in liver disease patients.

Summary:

Bisphosphonates, such as alendronate, may increase bone mineral density in chronic liver disease.
Vitamin D treatment could address prevalent deficiencies contributing to hepatic osteodystrophy.
Estrogen therapy is cautioned against due to potential liver dysfunction and hepatocellular carcinoma risks.

Impact:

Informs clinical practice regarding bone health management in chronic liver disease.
Highlights potential therapeutic avenues for hepatic osteodystrophy.
Provides guidance on medication selection, considering liver-specific risks.