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Growth Charts for Children With Down Syndrome in the United States

Babette S Zemel1, Mary Pipan2, Virginia A Stallings3

  • 1Divisions of Gastroenterology, Hepatology, and Nutrition, and Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; and zemel@email.chop.edu.

Pediatrics
|October 28, 2015
PubMed

Insights

New growth charts for children with Down syndrome (DS) show improved weight and height compared to older US data. These charts help assess growth and nutritional status in children with DS.

Area of Science:

  • Pediatrics
  • Genetics
  • Growth and Development

Background:

  • Children with Down syndrome (DS) historically exhibit lower birth weights and slower growth rates.
  • Improved medical care has enhanced overall well-being for individuals with DS, but growth trajectory changes remain unclear.

Purpose of the Study:

  • To develop novel growth charts specifically for children with Down syndrome.
  • To compare these new charts against existing US and UK growth data.

Main Methods:

  • The Down Syndrome Growing Up Study (DSGS) collected longitudinal growth data from 637 participants up to 20 years of age.
  • Sex-specific growth charts were created using the LMS method for age ranges birth to 36 months and 2 to 20 years.
  • Weight-for-length and BMI charts were also generated for comprehensive assessment.

Main Results:

  • Developed new DSGS growth charts based on 1520 measurements.
  • Charts for infants (<36 months) indicate significant weight improvements compared to older US charts.
  • Charts for older children (2-20 years) reveal increased height in contemporary males; overall, DSGS charts align closely with UK charts.

Conclusions:

  • The new DSGS growth charts serve as valuable screening tools for growth and nutritional status.
  • These charts facilitate comparisons of individual child growth against peers with Down syndrome.
  • The findings suggest positive trends in growth parameters for children with DS over time.
Abstract

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