Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From clinical fluids to environmental matrices: quantitative monitoring of infectious monkeypox virus based on PMA-qPCR during the Guangdong outbreak.

Tropical medicine and health·2026
Same author

Visible-Light-Induced Release of Carbon Monoxide: Multifunctionally Treatment for Dry Eye Disease.

Nano letters·2026
Same author

Towards sustainable pharmaceutical manufacturing: The rise of supercritical fluid technology.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model.

Exploration (Beijing, China)·2026
Same author

Bioinformatics identification of copyback and multihost-adapted defective viral genomes in dengue virus.

Frontiers in cellular and infection microbiology·2026
Same author

Mucoadhesive Nanothalidomide Enema: Simultaneous Radioprotection and Barrier Repair in Radiation Enteritis Therapy.

ACS nano·2026

Related Experiment Video

Updated: Mar 31, 2026

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

2.4K

Virus-mimetic nanovesicles as a versatile antigen-delivery system.

Pengfei Zhang1, Yixin Chen2, Yun Zeng3

  • 1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China;

Proceedings of the National Academy of Sciences of the United States of America
|October 28, 2015
PubMed
Summary

Developing novel vaccines is crucial for pandemic preparedness. This study introduces virus-mimetic nanovesicles (VMVs) that display viral antigens, offering a promising platform for rapid vaccine development against enveloped viruses.

Keywords:
antigen delivery systemcell membranenanobiotechnologyvaccinevirus-mimetic vesicle

More Related Videos

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

3.1K
Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

2.4K

Related Experiment Videos

Last Updated: Mar 31, 2026

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

2.4K
A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

3.1K
Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

2.4K

Area of Science:

  • Biotechnology
  • Virology
  • Vaccine Development

Background:

  • Rapid vaccine design is critical for managing pandemics.
  • Enveloped viruses utilize host cell membranes for replication and release.
  • Existing vaccine platforms may face challenges in speed and efficacy.

Purpose of the Study:

  • To engineer a novel nanobiotechnology platform for rapid vaccine development.
  • To create virus-mimetic nanovesicles (VMVs) displaying native viral antigens.
  • To establish VMVs as a versatile system for antigen delivery against enveloped viruses.

Main Methods:

  • Genetically engineering viral antigens into host cell membranes.
  • Utilizing surfactants to generate uniform, spherical virus-mimetic nanovesicles (VMVs).
  • Characterizing VMVs for size, shape, and display of conformational epitopes.

Main Results:

  • Successfully generated nano-sized VMVs resembling natural viruses in key characteristics.
  • VMVs effectively displayed native conformational epitopes and viral envelope glycoproteins.
  • Demonstrated the robustness and tunability of VMVs for antigen delivery.

Conclusions:

  • Virus-mimetic nanovesicles (VMVs) represent a straightforward and adaptable platform for vaccine fabrication.
  • VMVs show significant potential for developing rapid and effective vaccines against diverse enveloped viruses.
  • This nanobiotechnology approach offers a promising strategy for future pandemic preparedness.