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Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application.

Neda Naseri¹, Hadi Valizadeh², Parvin Zakeri-Milani³

¹Student Research Committee and Faculty of Advanced Medical Sciences, Department of Medical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.

Advanced Pharmaceutical Bulletin

|October 28, 2015

Summary

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are advanced lipid nanoparticles (LNPs) offering improved drug delivery. These lipid-based nanoparticles provide enhanced stability, loading capacity, and targeted delivery for various applications.

Keywords:

Colloidal carriers NLCs SLNs physical stability preparation methods

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Published on: November 17, 2015

Area of Science:

Nanotechnology and Materials Science
Pharmaceutical Sciences and Drug Delivery

Background:

Lipid nanoparticles (LNPs) have garnered significant attention in recent decades.
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) represent key advancements in lipid-based nanoparticle technology.
SLNs were designed to surpass limitations of earlier colloidal carriers, offering superior physical stability and controlled release.

Purpose of the Study:

To explore the features, structure, and innovations of lipid nanoparticles (LNPs).
To provide a comprehensive overview of preparation methods, benefits, drawbacks, and applications of LNPs, with a specific focus on SLNs and NLCs.

Main Methods:

Review and discussion of existing literature on lipid nanoparticle preparation and characterization.
Analysis of structural models and properties of SLNs and NLCs.
Comparative evaluation of advantages and disadvantages of SLNs and NLCs.

Main Results:

NLCs represent a second-generation LNP, enhancing the stability and drug-loading capacity of SLNs.
Three distinct structural models for NLCs have been proposed.
LNPs, particularly SLNs and NLCs, demonstrate broad potential across drug delivery, research, cosmetics, and clinical medicine.

Conclusions:

SLNs and NLCs offer significant advantages in drug delivery due to their stability and targeting capabilities.
Continued innovation in LNP technology, especially NLCs, promises to expand their therapeutic and commercial applications.
This review highlights the critical role of lipid nanoparticles in advancing pharmaceutical and biomedical fields.