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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Antimicrobial Activity Evaluation on Silver Doped Hydroxyapatite/Polydimethylsiloxane Composite Layer.

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Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Microbiology

Background:

  • Developing effective antimicrobial coatings is crucial for preventing medical device-associated infections.
  • Silver and hydroxyapatite are known for their antimicrobial and biocompatible properties, respectively.
  • Polydimethylsiloxane (PDMS) offers a versatile polymer matrix for composite materials.

Purpose of the Study:

  • To prepare and characterize novel silver-doped hydroxyapatite/polydimethylsiloxane (Ag:HAp-PDMS) composite layers.
  • To evaluate the physicochemical properties and antimicrobial efficacy of the developed composite layers.
  • To investigate the antibiofilm activity against Candida albicans.

Main Methods:

  • Deposition of PDMS polymer layer on silicon disks via atmospheric pressure corona discharges.
  • Fabrication of Ag:HAp-PDMS composite layers using thermal evaporation.
  • Characterization using Scanning Electron Microscopy (SEM), Glow Discharge Optical Emission Spectroscopy (GDOES), and X-ray photoelectron spectroscopy (XPS).
  • Antimicrobial assessment against Candida albicans using culture-based methods, SEM, and Confocal Laser Scanning Microscopy (CLSM).

Main Results:

  • Successful preparation and characterization of Ag:HAp-PDMS composite layers.
  • Demonstrated significant antimicrobial activity against Candida albicans.
  • Confirmed effective inhibition of Candida albicans biofilm formation by SEM and CLSM.

Conclusions:

  • The novel Ag:HAp-PDMS composite layers exhibit promising antimicrobial properties.
  • This material is effective in preventing Candida albicans biofilm development.
  • The findings suggest potential applications in biomedical devices for infection control.