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Updated: Mar 31, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C
Souvik Sarkar1, Kisha A Mitchell2, Joseph K Lim1
1Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT.
Abstract:
Sofosbuvir and simeprevir are used for the treatment of chronic hepatitis C (HCV) genotype 1. Both drugs have been well-tolerated, with diarrhea noted in 6% cases with sofosbuvir, 16% with sofosbuvir plus simeprevir, and 0% with simeprevir. No prior reports exist of colitis secondary to either drug or their combination. We report a patient with no prior history of inflammatory bowel disease who developed significant bloody diarrhea within 2 weeks of sofosbuvir/simeprevir initiation. Colonoscopy and biopsy confirmed pancolitis, which responded to mesalamine and completion of sofosbuvir/simeprevir.
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