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Updated: Mar 31, 2026

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
Published on: October 13, 2016
Anodal sensory nerve action potentials: From physiological understanding to potential clinical applicability
Joao Leote1, Pedro Pereira2, Christopher Cabib3
1Neurosurgery Department, Hospital Garcia de Orta, Almada, Portugal.
Introduction:
Low-intensity electrical stimuli of digital nerves may generate a double peak potential (DPp), composed of a cathodal (caAP) and an anodal (anAP) potential in orthodromic recordings.
Methods:
We studied the effects on caAP and anAP of stimuli of variable intensity, duration, and frequency. We also applied a conditioning stimulus to study potential differences in recovery time.
Results:
The anAP was obtained in 33 of 40 healthy subjects (82.5%) and 4 of 20 patients with various types of sensory neuropathies (20%). Changes in stimulus duration and intensity had reciprocal effects on the amplitude of the anAP and the caAP. There were significant differences in recovery time between caAP and anAP after a conditioning stimulus.
Conclusion:
The caAP and anAP are 2 interdependent waveforms generated by different effects of the same stimulus over axons at the verge of depolarization. Muscle Nerve 53: 897-905, 2016.
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