Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Insulin Formulations: Types and Delivery

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Production of Pharmaceuticals

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under...

Drug Products: Biologics, Biosimilars and Interchangeables

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...

Insulin: Biosynthesis, Chemistry, and Preparation

Insulin: Biosynthesis, Chemistry, and Preparation

The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Variant-aware computational assessment of neutralizing antibody binding robustness to botulinum toxin A.

Toxicon : official journal of the International Society on Toxinology·2026

Same author

Consensus computational immunogenicity modelling of botulinum neurotoxin serotypes: Cross-platform validation, uncertainty quantification, and relative risk assessment.

Toxicon : official journal of the International Society on Toxinology·2026

Same author

A mechanistic computational cell-based potency assay for botulinum neurotoxin A enables transparent potency estimation and cross-assay harmonization.

Toxicon : official journal of the International Society on Toxinology·2026

Same author

Excipient substitution in botulinum toxin type A formulations: Insights from multi-scale in silico modelling.

Journal of pharmaceutical sciences·2025

Same author

Breaking the 4-hour rule: Multiscale computational modelling redefines post-injection restrictions for botulinum neurotoxin A.

Toxicon : official journal of the International Society on Toxinology·2025

Same author

Beyond structural divergence: Multiscale computational immunogenicity modelling of botulinum neurotoxin E and cross-reactivity in botulinum neurotoxin A primed hosts.

Toxicon : official journal of the International Society on Toxinology·2025

Same journal

Healing from Within: Biologics in Facial Plastic Surgery.

Facial plastic surgery clinics of North America·2026

Same journal

The Natural Healing Force Within Each of Us.

Facial plastic surgery clinics of North America·2026

Same journal

US Food and Drug Administration and Regulation Issues for Biologics: The Sands Are Shifting.

Facial plastic surgery clinics of North America·2026

Same journal

Direct Injection of Stem Cells and Differentiated Cells: European Experience and Dubai Perspective.

Facial plastic surgery clinics of North America·2026

Same journal

A New Frontier of Cosmetic Technology: Modified mRNA for Personalized Applications.

Facial plastic surgery clinics of North America·2026

Same journal

Photobiomodulation and Biological Pathways in Skin Regeneration and Rejuvenation: Light and Biological Activation of Skin Improvement.

Facial plastic surgery clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 31, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

The Case for Synthetic Injectables.

John H Joseph¹

¹9400 Brighton Way, Suite 203, Beverly Hills, CA 90210, USA.

Facial Plastic Surgery Clinics of North America

|October 28, 2015

Summary

This summary is machine-generated.

This review compares permanent synthetic dermal fillers, focusing on medical-grade liquid injectable silicone and polymethyl methacrylate. It details their properties, clinical use, and adverse events for informed selection and application.

Keywords:

Acne scarring Dermal fillers Liquid injectable silicone Nasolabial folds Permanent fillers Polymethyl methacrylate Synthetic fillers

More Related Videos

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Related Experiment Videos

Last Updated: Mar 31, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Area of Science:

Dermatology
Plastic Surgery
Biomaterials Science

Background:

Synthetic dermal fillers offer various options for volume enhancement.
Semipermanent and permanent fillers are available in the United States.
Understanding filler properties is crucial for effective clinical use.

Purpose of the Study:

To review permanent synthetic injectables used in the US.
To compare medical-grade liquid injectable silicone and polymethyl methacrylate.
To elucidate their chemical, polymeric, and clinical profiles.

Main Methods:

Review of clinical and scientific evidence.
Analysis of chemical and polymeric properties.
Evaluation of clinical data, patient selection, indications, injection techniques, and adverse events.

Main Results:

Detailed profiles of medical-grade liquid injectable silicone and polymethyl methacrylate.
Comparison of advantages and disadvantages of each filler.
Insights into optimal circumstances for use based on product performance.

Conclusions:

Knowledge of unique characteristics aids in appropriate use of silicone and polymethyl methacrylate fillers.
Informed decisions regarding filler selection and application are supported by this review.
Understanding product performance enhances patient outcomes and safety.