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Updated: Mar 31, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
Published on: July 16, 2021
A perspective on stem cell modeling of amyotrophic lateral sclerosis
A Sophie de Boer1,2, Kevin Eggan1
1a The Howard Hughes Medical Institute; The Harvard Stem Cell Institute; The Stanley Center for Psychiatric Research ; The Department of Stem Cell and Regenerative Biology ; Harvard University ; Cambridge , MA USA.
Abstract:
Amyotrophic lateral sclerosis is a complex neurodegenerative disease. Limitations in animal models have impeded progress in studying disease pathology and potential drug discovery. Here, we will review recent advances in the development of stem cell models for the study of ALS. Additionally, we will discuss the progress toward therapeutic development derived from these stem cell based assays.
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