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Updated: Mar 31, 2026

Visualization of Metabolites Identified in the Spatial Metabolome of Traditional Chinese Medicine Using DESI-MSI
Published on: December 16, 2022
Imaging of drug and metabolite distribution by MS: case studies
1Research Laboratory for Development, Shionogi & Co. Ltd., Futaba 3-1-1, Toyonaka, Osaka 561-0825, Japan.
Abstract:
Analysis of drug and metabolite distribution is essential for understanding of the mechanisms underlying the pharmacological or toxicological effects. MS imaging (MSI) can visualize the distribution of drugs or biological molecules in tissue sections without radiolabeling, and distinguish between the distribution of a drug and that of its metabolites in tissue sections. Therefore, it is expected to be a potent imaging technique for drug distribution studies. This article includes cases in which MSI was used to analyze drug and metabolite distribution, and discusses the impact of data obtained by MSI in drug discovery and development.
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