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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Traumatic Memory01:20

Traumatic Memory

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Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
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Dissociative Disorders01:27

Dissociative Disorders

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Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
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Dissociative Identity Disorder01:30

Dissociative Identity Disorder

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Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
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Related Experiment Video

Updated: Mar 31, 2026

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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A Molecular Clue to PTSD.

Richard Robinson1

  • 1Freelance Science Writer, Sherborn, Massachusetts, United States of America.

Plos Biology
|October 28, 2015
PubMed
Summary

Reduced levels of the stress-regulated protein kinase SGK1 are linked to the development of post-traumatic stress disorder in both rats and humans. This finding offers new insights into the molecular mechanisms underlying PTSD.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Psychiatry

Background:

  • Post-traumatic stress disorder (PTSD) is a debilitating mental health condition.
  • The molecular underpinnings of PTSD are not fully understood.
  • Stress-related pathways are implicated in PTSD development.

Purpose of the Study:

  • To investigate the role of serum/glucocorticoid regulated kinase 1 (SGK1) in the pathophysiology of PTSD.
  • To examine SGK1 levels in animal models and human subjects with PTSD.

Main Methods:

  • Utilized rat models of PTSD.
  • Analyzed SGK1 protein levels in human subjects diagnosed with PTSD.
  • Employed biochemical assays to quantify SGK1 expression.

Main Results:

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  • Demonstrated a significant reduction in SGK1 levels in rats exposed to trauma.
  • Observed decreased SGK1 levels in human PTSD patients compared to controls.
  • Correlated reduced SGK1 with PTSD symptom severity.

Conclusions:

  • Reduced levels of SGK1 are associated with the development of PTSD.
  • SGK1 may represent a potential therapeutic target for PTSD treatment.
  • Further research is warranted to explore SGK1's precise role in stress-related disorders.