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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Updated: Mar 31, 2026

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Published on: October 27, 2020

Proteomic approach to nanotoxicity.

Magdalena Matysiak¹, Lucyna Kapka-Skrzypczak², Kamil Brzóska³

¹Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland.

Journal of Proteomics

|October 28, 2015

Summary

This summary is machine-generated.

Engineered nanomaterials offer benefits but may harm health and environment. Proteomics reveals their toxic effects on organisms, highlighting knowledge gaps for safer nanotechnology development.

Keywords:

Nanomaterials Nanoparticles Nanotoxicology Protein expression

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Area of Science:

Environmental science
Toxicology
Proteomics

Background:

Engineered nanomaterials (NMs) have diverse applications but raise environmental and health concerns.
Evidence suggests NMs can interact harmfully with biological systems.

Purpose of the Study:

To review proteomics approaches for assessing nanotoxicity.
To summarize the effects of NMs on organismal proteomes.

Main Methods:

Literature review of proteomics studies on nanotoxicity.
Analysis of in vitro and in vivo effects of NMs on proteomes.
Inclusion of environmentally relevant organisms.

Main Results:

Proteomics reveals NM interactions with biological systems.
NM exposure affects proteomes across diverse organisms (bacteria, plants, mammals).
Effects on environmentally relevant organisms are also detailed.

Conclusions:

Gaps in knowledge regarding NM impact on human health and environment persist.
Interdisciplinary research using "OMICS" techniques is needed.
Holistic approaches are crucial for understanding NM toxicity.