Related Experiment Video

Updated: Mar 31, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

14.7K

Pulmonary hypoplasia with associated cardiac and skeletal malformations

Efrén Martínez-Quintana, Fayna Rodríguez-González

    Pneumologia (Bucharest, Romania)
    |October 29, 2015
    PubMed

    Insights

    Pulmonary hypoplasia, a lung development disorder, can present with few symptoms but often involves other congenital anomalies. This case highlights complex associated cardiac, skeletal, and vascular defects in a young male patient.

    Area of Science:

    • Cardiology
    • Pulmonology
    • Pediatric Surgery
    • Medical Genetics

    Background:

    • Pulmonary hypoplasia is a congenital condition characterized by incomplete lung development.
    • While often associated with mild respiratory symptoms, it can present with significant comorbidities.
    • Associated anomalies frequently involve cardiac, gastrointestinal, genitourinary, and skeletal systems.

    Observation:

    • A 17-year-old male presented with a hypoplastic right lung.
    • The patient exhibited secondary cardiac dextroposition and an ostium secundum atrial septal defect.
    • Additional findings included a hypoplastic right pulmonary artery with a retrocaval course, vertebral fusion, and pollicization secondary to thumb hypoplasia.

    Findings:

    • The case details a rare constellation of congenital anomalies secondary to right pulmonary hypoplasia.
    • The anatomical abnormalities included dextroposition of the heart, atrial septal defect, and aberrant pulmonary artery development.
    • Skeletal anomalies, specifically vertebral fusion and thumb abnormalities (pollicization), were also noted.

    Implications:

    • This case underscores the importance of comprehensive evaluation for associated anomalies in patients with pulmonary hypoplasia.
    • Understanding these complex associations aids in diagnosis and management planning.
    • Further research into the genetic and developmental pathways of pulmonary hypoplasia and its related defects is warranted.

    More Related Videos

    Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet09:22

    Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

    Published on: November 4, 2015

    12.7K
    A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse08:19

    A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

    Published on: December 16, 2022

    2.5K

    Related Concept Videos

    Pulmonary Hypertension: Classification and Pathogenesis01:30

    Pulmonary Hypertension: Classification and Pathogenesis

    Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
    There are various classifications for PH, each relating to different underlying causes and also...
    847
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    708
    Pulmonary Embolism I: Introduction01:29

    Pulmonary Embolism I: Introduction

    Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
    1.2K
    Teratogenicity01:07

    Teratogenicity

    The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
    4.5K
    Mitral Stenosis I: Introduction01:22

    Mitral Stenosis I: Introduction

    Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
    1.3K
    Mitral Valve Prolapse I: Introduction01:27

    Mitral Valve Prolapse I: Introduction

    IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
    925