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The Association Between Baseline Left Atrial Volume Index and All-Cause Mortality in Patients with Heart Failure: A
Connecticut Medicine
|October 29, 2015
Summary
Left atrial volume index (LAVI) is a significant predictor of mortality in heart failure (HF) patients. Each 10 mL/m2 increase in baseline LAVI correlates with a 22% higher risk of all-cause mortality.
Area of Science:
- Cardiology
- Echocardiography
- Prognostic Biomarkers
Background:
- Left atrial enlargement is a known mortality risk factor in the general population.
- Left atrial volume index (LAVI) is a proposed prognostic measure for heart failure (HF).
Purpose of the Study:
- To evaluate baseline LAVI as an independent predictor of all-cause mortality in HF patients.
- To synthesize evidence from existing studies on the prognostic value of LAVI in heart failure.
Main Methods:
- Systematic meta-analysis of four studies identified via Medline and Embase.
- Inclusion criteria: HF cohorts, multivariate analysis of LAVI and mortality, reported data on LAVI (mL/m2) and all-cause mortality.
- Pooled adjusted hazard ratios using random-effects meta-analysis.
Main Results:
- A 10 mL/m2 increase in baseline LAVI was associated with a 22% increased adjusted hazard of all-cause mortality.
- Confidence interval for this association was 13% to 31% (I2 = 14%).
Conclusions:
- Baseline LAVI is a crucial independent predictor of all-cause mortality in heart failure.
- Routine reporting of LAVI in echocardiography for HF patients is recommended.
