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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Related Experiment Video

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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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HEMOSTATIC STUDIES IN DENGUE PATIENTS.

Darintr Sosothikul, Usa Thisyakorn, Chule Thisyakorn

    The Southeast Asian Journal of Tropical Medicine and Public Health
    |October 29, 2015
    PubMed
    Summary

    Dengue virus causes vasculopathy, thrombocytopenia, and coagulopathy. Plasma von Willebrand factor antigen (VWF:Ag) is the best indicator for predicting severe dengue progression.

    Area of Science:

    • Hematology
    • Virology
    • Pathophysiology

    Background:

    • The pathogenesis of hematologic changes in dengue patients remains unclear.
    • Consistent findings include vasculopathy, thrombocytopenia, and coagulopathy.
    • Dengue virus infection triggers pathophysiological changes affecting these hematologic parameters.

    Purpose of the Study:

    • To investigate endothelial cell activation and hemostatic system changes in dengue patients.
    • To correlate these changes with clinical severity.
    • To identify the best prognostic factor for severe dengue.

    Main Methods:

    • Assessed endothelial cell activation and hemostatic system markers.
    • Correlated laboratory findings with clinical severity.
    • Evaluated prognostic indicators for severe dengue.

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    Main Results:

    • Dengue virus infection leads to vasculopathy, reduced platelet count and function, and decreased coagulation factors.
    • Evidence of disseminated intravascular coagulation (DIC) is present across all dengue severity levels.
    • Plasma von Willebrand factor antigen (VWF:Ag) levels were the strongest indicator of progression to severe dengue.

    Conclusions:

    • Dengue virus significantly impacts the hematologic and hemostatic systems.
    • Profound DIC, particularly in severe cases, contributes to uncontrolled bleeding and mortality.
    • Plasma VWF:Ag is a reliable prognostic biomarker for identifying patients at risk of severe dengue.