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TOR1A, THAP1, and GNAL mutational screening in Austrian patients with primary isolated dystonia

Michael Zech1,2, Sylvia Boesch3, Thomas Sycha4

  • 1Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Movement Disorders : Official Journal of the Movement Disorder Society
|October 29, 2015
PubMed
Abstract

No abstract available in PubMed .

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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