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Updated: Mar 31, 2026

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes?
Guan-Zheng Luo1, Mario Andres Blanco2, Eric Lieberman Greer3
1Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, and the Howard Hughes Medical Institute, 929 East 57th Street, Chicago, Illinois 60637, USA.
None:
DNA N(6)-adenine methylation (N(6)-methyladenine; 6mA) in prokaryotes functions primarily in the host defence system. The prevalence and significance of this modification in eukaryotes had been unclear until recently. Here, we discuss recent publications documenting the presence of 6mA in Chlamydomonas reinhardtii, Drosophila melanogaster and Caenorhabditis elegans; consider possible roles for this DNA modification in regulating transcription, the activity of transposable elements and transgenerational epigenetic inheritance; and propose 6mA as a new epigenetic mark in eukaryotes.
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