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On the information content of the genetic code.

T Alvager1, G Graham, R Hilleke

  • 1Physics Department, Indiana State University, Terre Haute 47809.

Bio Systems
|January 1, 1989
PubMed
Summary

The genetic code

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Information Theory

Background:

  • The genetic code uses 64 codons to encode 20 amino acids and terminators.
  • A fundamental question in genetics is why codon degeneracies are distributed as they are.

Purpose of the Study:

  • To investigate the degeneracy of the genetic code using information theory.
  • To explore the relationship between codon degeneracy and information optimization.

Main Methods:

  • Numerical evaluation of a degeneracy information function.
  • Analysis of codon assignments in the standard genetic code.

Main Results:

  • The study reveals a connection between the observed codon degeneracy and the optimization of a specific information function.
  • Direct numerical evaluation supports the information-theoretic explanation for genetic code degeneracy.

Conclusions:

  • The degeneracy of the genetic code is not random but is linked to the optimization of an information function.
  • Information theory provides a framework for understanding the structural properties of the genetic code.

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