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Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

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Published on: January 24, 2016

HIF3α: the little we know.

Linda Ravenna¹, Luisa Salvatori¹, Matteo A Russo²

¹CNR, Institute of Molecular Biology and Pathology, Rome, Italy.

The FEBS Journal

|October 29, 2015

Summary

Hypoxia-inducible factor 3 alpha (HIF3α) variants regulate gene expression and cellular responses. This review synthesizes current knowledge on HIF3α

Keywords:

HIF3α hypoxia hypoxia-inducible factors pathology splice variants transcriptional regulation

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Published on: March 24, 2015

Area of Science:

Molecular Biology
Cellular Biology
Genetics

Background:

Hypoxia-inducible factors (HIFs) are critical for cellular adaptation to low oxygen.
HIF1α and HIF2α are well-studied, but HIF3α remains less understood.
The HIF3α gene exhibits complex regulation producing diverse splice variants.

Purpose of the Study:

To review the structure, expression, and functions of HIF3α variants.
To consolidate fragmented and sometimes conflicting data on HIF3α.
To explore HIF3α roles in both hypoxic and normoxic conditions and its pathological implications.

Main Methods:

Literature review of existing studies on HIF3α.
Analysis of splice variants and their protein products.
Examination of regulatory mechanisms and functional roles.

Main Results:

HIF3α variants act as negative regulators of HIF1α/HIF2α and transcriptional activators.
Diverse roles of HIF3α variants depend on the specific variant and biological context.
HIF3α deregulation is linked to pathological conditions.

Conclusions:

HIF3α plays multifaceted roles beyond hypoxia response.
Further research is needed to fully elucidate HIF3α variant functions.
Understanding HIF3α is crucial for its therapeutic targeting in various diseases.