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All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

Jaya Sangodkar1, Caroline C Farrington2, Kimberly McClinch3

  • 1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

The FEBS Journal
|October 29, 2015
PubMed

Insights

Protein phosphatase 2A (PP2A) is a tumor suppressor crucial for cellular processes. This review explores PP2A

Area of Science:

  • Molecular biology
  • Biochemistry
  • Oncology

Background:

  • Protein phosphatase 2A (PP2A) regulates numerous cellular functions.
  • PP2A acts as a tumor suppressor, and its inactivation is common in cancers.
  • Therapeutic strategies to restore PP2A function are needed for cancer treatment.

Purpose of the Study:

  • To review recent literature on Protein phosphatase 2A (PP2A).
  • To discuss PP2A structure, subunit functions, and cancer-related dysregulation.
  • To explore therapeutic targets modulating PP2A for cancer treatment.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of structural and functional data of PP2A.
  • Examination of molecular mechanisms of PP2A dysregulation in cancer.

Main Results:

  • Recent studies have elucidated PP2A structure and subunit roles.
  • Molecular lesions and post-translational modifications contribute to PP2A dysregulation in cancer.
  • Proteins and small molecules modulating PP2A are identified.

Conclusions:

  • Understanding PP2A's structure and function is key to its therapeutic reactivation.
  • Targeting dysregulated PP2A offers potential treatment strategies for cancers.
  • Modulators of PP2A may be useful in treating various diseases.
Keywords:
CIP2APP2ASETcancercancer biologycell signalingdrug developmentprotein phosphatasesstructural biologytumor suppressors

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