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Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique
Published on: November 9, 2018
Severe acute measles pneumonitis: virus isolation in bronchoalveolar lavage fluid
Cosima Suter1, Urs Buergi1, Katja Eigenmann2
1University Hospital Zürich, Zürich, Switzerland.
Abstract:
In the past few years, several endemic outbreaks of measles have been recognised, not only in children but also in adults, with severe and, occasionally, even fatal complications, possibly due to delayed diagnosis of the disease in adult medicine and decreasing vaccination rates. Furthermore, the treatment consists of supportive measures only. We present a case of severe measles pneumonitis in a 42-year-old man, a travel returnee, proven by direct virus isolation with PCR from bronchoalveolar lavage fluid. CT findings and pulmonary function testing revealed features of obstructive bronchiolitis; the patient was successfully treated with corticosteroids. He fully recovered, and lung function measurement returned to normal values. We conclude that acute measles can present as obstructive bronchiolitis and may be successfully treated with corticosteroids.
Insights
Measles outbreaks are increasing in adults, often leading to severe complications. This case highlights that measles can cause obstructive bronchiolitis, successfully treated with corticosteroids.
Area of Science:
- Infectious Diseases
- Pulmonology
- Virology
Background:
- Measles outbreaks are increasingly recognized in adults, presenting with severe complications.
- Delayed diagnosis in adult medicine and declining vaccination rates contribute to measles severity.
- Current measles treatment relies solely on supportive measures.
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