Related Experiment Video

Updated: Mar 31, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

3.0K

The role of miRNAs in cutaneous squamous cell carcinoma

Xin Yu1, Zheng Li1

  • 1Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal of Cellular and Molecular Medicine
|October 29, 2015
PubMed

Insights

MicroRNAs (miRs) are key regulators in cancer. This study reviews their role in cutaneous squamous cell carcinoma (cSCC), highlighting their potential as diagnostic biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRs) are small, noncoding RNAs regulating gene expression post-transcriptionally.
  • Aberrant miR expression is implicated in cancer initiation and progression.
  • miRs play significant roles in various biological processes, including cell apoptosis and proliferation.

Purpose of the Study:

  • To summarize current data on microRNAs associated with cutaneous squamous cell carcinoma (cSCC).
  • To discuss the contribution of miRs to cSCC initiation and progression.
  • To explore the future clinical potential of miRs in cSCC diagnosis, prognosis, and therapy.

Main Methods:

  • Literature review and data summarization.
  • Analysis of existing studies on miR expression in cSCC.
  • Discussion of oncogenic and tumor-suppressive roles of miRs in cSCC.

Main Results:

  • miRs are significantly deregulated in cSCC, acting as oncogenic or tumor-suppressive molecules.
  • Specific miRs contribute to the initiation and progression of cSCC.
  • miRs have demonstrated potential in regulating key cellular processes relevant to cSCC.

Conclusions:

  • miRs are crucial in cSCC pathogenesis.
  • Further research into miR expression and function will advance cSCC understanding.
  • Clinical applications of miRs as biomarkers and therapeutic targets in cSCC are promising.
Keywords:
cutaneous squamous cell carcinomamiRmicroRNAsoncogene

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.7K
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

505

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
MicroRNAs01:22

MicroRNAs

12.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.3K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K