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Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
Targeted anticancer drug delivery through anthracycline antibiotic bearing functionalized quantum dots
Neha Bajwa1, Neelesh Kumar Mehra1, Keerti Jain1
1a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India.
Abstract:
We herein first report a method for the synthesis of chitosan (CHI)-folate conjugated colloidal ZnO-Mn(+2) quantum dots (QDs) bearing doxorubicin through chemical method (DOX/FA-CHI-QDs) for cancer therapy as well imaging purpose. The entrapment efficiency was determined to be 99.98 ± 0.012% (DOX/FA-CHI-QDs) and 92.0 ± 2.62% (DOX-QDs). The developed DOX/FA-CHI-QDs formulations depict the sustained release pattern at the lysosomal pH (pH 5.0). The DOX/FA-CHI-QDs showed enhanced cytotoxicity, cellular uptake and were most preferentially taken up by the cancerous cells via receptor-mediated endocytosis (RME) mechanism. Hence, the QD-based formulation is capable of targeting drug delivery and imaging the delivery process.
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