Related Experiment Video
Updated: Jan 9, 2026
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor
Nathan C Sheffield1, Christoph Bock2
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences.
Unlabelled:
Genomic datasets are often interpreted in the context of large-scale reference databases. One approach is to identify significantly overlapping gene sets, which works well for gene-centric data. However, many types of high-throughput data are based on genomic regions. Locus Overlap Analysis (LOLA) provides easy and automatable enrichment analysis for genomic region sets, thus facilitating the interpretation of functional genomics and epigenomics data.
Availability And Implementation:
R package available in Bioconductor and on the following website: http://lola.computational-epigenetics.org.
