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Increased mean platelet volume in patients with panic disorder
Mehmet Hanifi Kokacya1, Umit Sertan Copoglu1, Yüksel Kivrak2
1Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Neuropsychiatric Disease and Treatment
|October 29, 2015
Summary
Mean platelet volume (MPV), a marker of platelet activity, was significantly higher in patients with panic disorder (PD) compared to healthy controls. This finding may link platelet function to PD and cardiovascular disease risk.
Area of Science:
- Hematology
- Psychiatry
- Cardiovascular Disease Research
Background:
- Platelet activation is linked to psychiatric disorders.
- Mean platelet volume (MPV) indicates platelet activity and is elevated in cardiovascular diseases (CVDs).
- Anxiety is a known risk factor for CVD mortality.
Purpose of the Study:
- To investigate differences in MPV between patients with panic disorder (PD) and healthy individuals.
- To explore the potential relationship between platelet activity and PD.
Main Methods:
- Sixty-one drug-free patients diagnosed with PD (aged 18-65) were compared to 63 age- and sex-matched healthy volunteers.
- Body mass index (BMI) and MPV were measured for all participants.
- PD diagnosis followed DSM-IV criteria.
Main Results:
- MPV was significantly higher in the PD group than in the control group (P=0.004).
- No significant differences in platelet count or BMI were observed between the groups.
Conclusions:
- Elevated MPV in PD patients suggests altered platelet activity.
- This may relate to central nervous system 5-hydroxytryptamine (5-HT) 1A receptor function.
- Findings may clarify the link between PD and CVDs.
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