Single Nodular Pulmonary Amyloidosis: Case Report

Area of Science:

• Pulmonary Medicine
• Pathology
• Rare Diseases

Background:

• Amyloidosis involves extracellular deposits of insoluble fibrillar protein.
• Pulmonary amyloidosis presents as tracheobronchial, nodular parenchymal, or diffuse alveolar septal types.
• Nodular pulmonary amyloidosis can be misdiagnosed as malignancy or infection.

Purpose of the Study:

• To report a unique case of single nodular pulmonary amyloidosis.
• To discuss the diagnostic challenges and clinical implications of this rare condition.
• To contribute to the limited literature on nodular pulmonary amyloidosis in Korea.

Main Methods:

• Case report of a patient with single nodular pulmonary amyloidosis.
• Review of clinical presentation, imaging findings, and histopathological results.
• Discussion of differential diagnoses and management strategies.

Main Results:

• A single nodular lesion of pulmonary amyloidosis was identified.
• The lesion mimicked other pulmonary conditions, highlighting diagnostic difficulties.
• This represents a distinct presentation from the previously reported multiple nodular case in Korea.

Conclusions:

• Single nodular pulmonary amyloidosis is a rare entity with potential for misdiagnosis.
• Accurate diagnosis requires a high index of suspicion and thorough investigation.
• This case underscores the importance of considering amyloidosis in the differential diagnosis of solitary pulmonary nodules.