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Updated: Mar 31, 2026
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
[Ventilator associated pneumonia in a neonatal intensive care unit]
Dassaev Izelo-Flores1, Fortino Solórzano-Santos, María Guadalupe Miranda-Novales
1Departamento de Infectología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Distrito Federal, México. guadalumiranda@terra.com.mx.
Background:
The studies that describe risk factors for the development of ventilator-associated pneumonia (VAP) in newborn infants report dissimilar information, possibly related to the type of intensive care unit and population included. The objective of this study was to identify risk factors for the development of VAP in a neonatal intensive-care unit.
Methods:
Case-control study. Patients with the diagnosis of VAP were classified as cases and compared with two controls of the same gestational age, weight, and diagnosis at admission. We analysed the data using descriptive and inferential statistics: chi-squared test, Student's t-test, odds-ratio, 95 % confidence interval and logistic regression analysis.
Results:
A total of 45 cases and 90 controls were analysed. The risk factors statistically significant in the univariate analysis were: previous episode of sepsis, reintubation, airway malformation, exclusive parenteral nutrition, and days of mechanical ventilation. In the logistic regression analysis we obtained these data: reintubation (OR 41.26, CI 95 % 11.9-158.4, p = 0.001), airway malformation (OR 19.5, CI 95 % 1.34-282.3, p = 0.029), and days of mechanical ventilation (OR 8.9, CI 95 % 1.9-40.8, p = 0.005). These were the only risk factors independently associated to VAP.
Conclusion:
Of the significant risk factors, it is possible to intervene in reintubation events, by securing the endotracheal cannula with an adequate fixation, mobilize the patient ensuring safety, and follow a decannulation protocol to reduce ventilation days.
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