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[Cardiovascular risk factors in children with primary nephrotic syndrome]

Gabriela Alejandra Alegría-Torres1, María Alejandra Aguilar-Kitsu, María Jesús Estrada-Loza

  • 1Servicio de Nefrología , Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. miguel.villasis@imss.gob.mx.

Revista Medica Del Instituto Mexicano Del Seguro Social
|October 29, 2015
PubMed

Insights

Children with nephrotic syndrome (NS) frequently experience cardiovascular risk factors, with nearly all having at least one. Steroid-resistant NS and longer disease duration correlate with more risk factors, highlighting the need for early intervention.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health
  • Clinical Research

Background:

  • Nephrotic syndrome (NS) is associated with increased cardiovascular risk factors.
  • Understanding these risks in children with primary NS is crucial for management.

Purpose of the Study:

  • To determine the frequency of cardiovascular risk factors in children with primary NS.
  • To identify clinical features associated with a higher burden of cardiovascular risk.

Main Methods:

  • A cross-sectional, descriptive, and prospective study of 55 children with primary NS.
  • Evaluated overweight/obesity, hypertension, dyslipidemias, hyperglycemia, C-reactive protein, and carotid intima-media thickness (IMT).
  • Analyzed treatment duration, type, and relapse frequency; used chi-square and Spearman's rho for statistics.

Main Results:

  • Increased carotid IMT (98.1%) was the most prevalent risk factor, followed by hypertriglyceridemia (54.4%) and high total cholesterol (40%).
  • Children with corticosensitive NS had fewer risk factors than those with steroid-resistant NS.
  • Longer disease duration and more relapses correlated with an increased number of risk factors.

Conclusions:

  • Nearly all children (98%) with primary NS exhibit at least one cardiovascular risk factor.
  • Steroid-resistant NS, prolonged disease evolution, and treatment duration are linked to a greater number of cardiovascular risk factors.
  • These findings underscore the importance of monitoring and managing cardiovascular health in pediatric NS.
Abstract

Keywords:
Carotid intima-media thicknessDyslipidemiasHypertensionNephrotic syndromeObesity

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