Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung serotonin metabolism.

C M Hart1, E R Block

  • 1Department of Medicine, University of Florida College of Medicine, Gainesville.

Clinics in Chest Medicine
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Measuring serotonin (5-HT) uptake in the lungs can detect early signs of lung injury before other tests. This sensitive method may lead to earlier treatment and improved patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender bias in assessing narcissistic personality: Exploring the utility of the ICD-11 dimensional model.

The British journal of clinical psychology·2024
Same author

Electrophysiological markers of mind wandering: A systematic review.

NeuroImage·2022
Same author

Hypoxia downregulates PPARγ via an ERK1/2-NF-κB-Nox4-dependent mechanism in human pulmonary artery smooth muscle cells.

Free radical biology & medicine·2013
Same author

Plastic transistors in active-matrix displays. The handling of grey levels by these large displays paves the way for electronic paper.

Nature·2001
Same author

Peroxynitrite causes endothelial cell monolayer barrier dysfunction.

American journal of physiology. Cell physiology·2001
Same author

Phenylarsine oxide inhibits nitric oxide synthase in pulmonary artery endothelial cells.

Free radical biology & medicine·2001
Same journal

Pneumonia Reimagined: Host, Microbe, and the Shifting Landscape of Disease.

Clinics in chest medicine·2026
Same journal

Advocacy in Pneumonia.

Clinics in chest medicine·2026
Same journal

Vaccines Against Pneumonia: Current Updates.

Clinics in chest medicine·2026
Same journal

Non-antibiotic Treatments for Pneumonia: Host-Directed Therapies, Next-Steps and Future Directions.

Clinics in chest medicine·2026
Same journal

Customizing Antibiotic Treatment for Pneumonia: Can We Have a Single Unified Algorithm for All Types of Pneumonia?

Clinics in chest medicine·2026
Same journal

The Role of Complex Digital Interventions to Improve Pneumonia Care.

Clinics in chest medicine·2026
See all related articles

Area of Science:

  • Pulmonary vascular biology
  • Endothelial cell function
  • Lung injury pathogenesis

Background:

  • The pulmonary vascular endothelium is a key site of injury in lung disease.
  • Serotonin (5-HT) removal is an early metabolic function depressed in lung injury.
  • Altered 5-HT uptake precedes conventional diagnostic markers of lung injury.

Purpose of the Study:

  • To highlight the potential of measuring 5-HT uptake as an early diagnostic tool for lung injury.
  • To discuss the challenges and future directions in developing clinical methods for 5-HT uptake measurement.

Main Methods:

  • Review of experimental evidence on 5-HT uptake in lung injury models.
  • Discussion of variables confounding clinical measurements of 5-HT uptake.

Related Experiment Videos

Main Results:

  • Depressed 5-HT uptake is an early indicator of endothelial dysfunction in lung injury.
  • Increased pulmonary 5-HT concentrations due to impaired uptake may contribute to injury progression.

Conclusions:

  • Measuring 5-HT uptake offers a sensitive method for early detection of diffuse lung injury.
  • Refinement of clinical measurement techniques could provide a valuable diagnostic tool for critically ill patients.
  • Earlier detection may enable timely interventions to prevent severe lung injury progression.