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Updated: Mar 31, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Induced Decarboxylative Functionalization of Carboxylic Acids and Their Derivatives
Jun Xuan1, Zhao-Guo Zhang2, Wen-Jing Xiao3
1CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei 430079 (China) http://chem-xiao.ccnu.edu.cn/
Abstract:
Visible-light-induced radical decarboxylative functionalization of carboxylic acids and their derivatives has recently received considerable attention as a novel and efficient method to create CC and CX bonds. Generally, this visible-light-promoted decarboxylation process can smoothly occur under mild reaction conditions with a broad range of substrates and an excellent functional-group tolerance. The radical species formed from the decarboxylation step can participate in not only single photocatalytic transformations, but also dual-catalytic cross-coupling reactions by combining photoredox catalysis with other catalytic processes. Recent advances in this research area are discussed herein.
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