Related Experiment Video
Updated: Mar 31, 2026
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Multidisciplinary decision making in the management of hepatocellular carcinoma: A hospital-based study
Saad Zaky1, Nahed A Makhlouf, Mohamed O Abdel Malek
1Department of Tropical Medicine and Gastroenterology, Assiut University Faculty of Medicine, Assiut, Egypt. nahedmak@yahoo.com.
Insights
Multidisciplinary team decisions for Hepatocellular carcinoma (HCC) management show comparable short-term outcomes for surgery and local ablative therapy (LAT). Conventional transarterial chemoembolization (TACE) demonstrated a lower success rate in this study.
Area of Science:
- Hepatology
- Oncology
- Surgical Oncology
Background:
- Hepatocellular carcinoma (HCC) management requires careful consideration of treatment options.
- A multidisciplinary team approach, such as a Hepatoma Board, is crucial for optimal patient care.
- Evaluating the short-term outcomes of treatment decisions is essential for refining clinical practice.
Purpose of the Study:
- To assess the short-term efficacy of Hepatocellular carcinoma (HCC) treatments decided by a multidisciplinary Hepatoma Board.
- To compare the outcomes of surgical resection, local ablative therapy (LAT), transarterial chemoembolization (TACE), and supportive care for HCC.
Main Methods:
- A prospective descriptive study was conducted on 74 patients diagnosed with HCC.
- Treatment decisions included surgical resection, LAT, TACE, and palliative care.
- Short-term outcomes were evaluated based on mortality, success rates, and biochemical markers.
Main Results:
- The overall short-term mortality rate was 25.7%.
- Success rates for LAT (68.2%) and surgery (71.4%) were comparable, while TACE showed a 33.3% success rate.
- Significant decreases in alpha-fetoprotein were observed after surgery and LAT, and in serum albumin after TACE.
Conclusions:
- Multidisciplinary team decisions are beneficial for managing Hepatocellular carcinoma (HCC).
- Surgical resection and LAT offer comparable outcomes, with surgery being more invasive.
- Conventional TACE demonstrated a limited success rate in this cohort.
Background/Aims:
To evaluate the short-term outcome of the decision taken by the Hepatoma Board for the treatment of Hepatocellular carcinoma (HCC).
Materials And Methods:
This was a prospective descriptive study involving 74 patients with HCC diagnosed by the known criteria. The decisions taken by the Hepatoma Board for the 74 patients were as follows: 1- surgical resection (7 patients), 2- local ablative therapy (LAT) (22 patients), 3- conventional transarterial chemoembolization (TACE) (24 patients), and 4- palliative supportive care (21 patients).
Results:
The short-term mortality rate was 25.7% of the total patients. The success rate was nearly equal in LAT (68.2%) and surgery (71.4%), whereas the success rate was approximately 33.3% in TACE. There was no difference in the mean total bilirubin level before and after LAT, surgery, or TACE (p>0.05 for each). There was a significant decrease in the mean serum albumin level after TACE (p=0.000). There was a decrease in the mean alpha fetoprotein level after surgery and LAT (p=0.033) for surgery and (p=0.048) for LAT.
Conclusion:
The management of HCC is better performed through a multidisciplinary team decision. Surgery has comparable outcome to LAT but is more invasive. According to our local experience, conventional TACE has a success rate of 33.3%.
More Related Videos
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
06:11Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique
Published on: May 2, 2025
Related Concept Videos
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow