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Centromere proteins. I. Mitosis specific centromere antigen recognized by anti-centromere autoantibodies
G Hadlaczky1, T Praznovszky, I Rasko
1Institute of Genetics, Hungarian Academy of Sciences, Szeged.
Chromosoma
|January 1, 1989
Abstract:
Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr = 59,000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mitotic chromosomes proved to be DNase I sensitive. In interphase nuclei, this centromere antigen was not detectable by immunoblot techniques. The results suggest that the Mr = 59,000 mitosis specific protein may be necessary for the structural stability of kinetochores during mitosis.