Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Severe hypoglycemia in IDDM children.

I Bergada1, S Suissa, J Dufresne

  • 1Diabetes Unit, Montreal Children's Hospital, McGill University Research Institute, Quebec, Canada.

Diabetes Care
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individual- and Neighborhood-Level Predictors of HIV Care Continuum Progression: Clark County, Nevada.

Open forum infectious diseases·2025
Same author

Pioglitazone and bladder cancer: improving research methods.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

A systematic review of observational studies of the association between pioglitazone use and bladder cancer.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Drospirenone-containing oral contraceptive pills and the risk of venous thromboembolism: a systematic review of observational studies.

BJOG : an international journal of obstetrics and gynaecology·2017
Same author

Cardiotoxicity of aromatase inhibitors and tamoxifen in postmenopausal women with breast cancer: a systematic review and meta-analysis of randomized controlled trials.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Drospirenone-containing combined oral contraceptives and the risk of arterial thrombosis: a population-based nested case-control study.

BJOG : an international journal of obstetrics and gynaecology·2016
Same journal

A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes.

Diabetes care·2026
Same journal

Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.

Diabetes care·2026
Same journal

State Insulin Out-of-Pocket Cap Policies and Estimated Eligible Populations in the United States, 2019-2026.

Diabetes care·2026
Same journal

Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.

Diabetes care·2026
Same journal

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes.

Diabetes care·2026
Same journal

Real-Time Continuous Glucose Monitoring Among People With Type 2 Diabetes and End-Stage Kidney Failure Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.

Diabetes care·2026
See all related articles

Severe hypoglycemia in children with insulin-dependent diabetes mellitus (IDDM) is often recurrent. Higher insulin doses and prior episodes predict future risk, not age or glucose control.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Diabetes Management

Background:

  • Severe hypoglycemia is a significant complication in pediatric patients with insulin-dependent diabetes mellitus (IDDM).
  • Understanding risk factors is crucial for preventing adverse events in this population.

Purpose of the Study:

  • To determine the incidence of severe hypoglycemia in a cohort of children with IDDM.
  • To identify predictors of severe hypoglycemia in this group.

Main Methods:

  • A 1-year prospective study involving 350 children with IDDM.
  • Comparison of demographic, clinical, and treatment variables between patients with and without severe hypoglycemia.
  • Logistic regression analysis to identify risk factors.

Related Experiment Videos

Main Results:

  • The incidence of severe hypoglycemia was 6.8% (25 episodes in 24 patients).
  • Higher insulin doses (P=.04) and a history of previous severe hypoglycemia (P=.01) were significantly associated with recurrent episodes.
  • Age, glycosylated hemoglobin, and duration of disease were not significant predictors.
  • Unusual circumstances preceded only 64% of episodes.

Conclusions:

  • Severe hypoglycemia is a recurrent issue in some children with IDDM, independent of age or glycemic control.
  • Previous episodes of severe hypoglycemia and higher insulin doses are key risk factors.
  • Strategies like regular monitoring, consistent meal timing, and adjusted food intake for activity may mitigate risk.