Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct contributions of two subpopulations of subthalamic neurons to levodopa-induced dyskinesia.

Science advances·2026
Same author

Research on spatial motion distance features of human body joint points based on dual-video acquisition experimental environment.

Scientific reports·2026
Same author

Calcium influx drives m6A-dependent RUNX1T1 splicing to promote adipogenic commitment.

Cell reports·2026
Same author

MARCHF6 orchestrates hepatic lipid homeostasis by targeting SREBP1 for ER-associated degradation.

Journal of hepatology·2026
Same author

Individual Outdoor Activity is Associated with Lower Mortality Among Older Chinese Adults: A Prospective Cohort Study.

Journal of prevention (2022)·2026
Same author

Integrative analysis of single-neuron projectomes links connectome, transcriptome, and function in the mouse cortex.

Neuron·2025

Related Experiment Video

Updated: Mar 31, 2026

An Operant Intra-/Extra-dimensional Set-shift Task for Mice
08:35

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

12.9K

Contrast-dependent orientation discrimination in the mouse.

Minghai Long1,2, Weiqian Jiang1,2, Dechen Liu1,2

  • 1Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Scientific Reports
|October 30, 2015
PubMed
Summary

Mouse visual task performance improves with stimulus contrast. High contrast orientation discrimination is better with single contrast stimuli, due to adapted V1 neural processing.

More Related Videos

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks
08:42

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks

Published on: August 4, 2018

15.3K
Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

78.6K

Related Experiment Videos

Last Updated: Mar 31, 2026

An Operant Intra-/Extra-dimensional Set-shift Task for Mice
08:35

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

12.9K
Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks
08:42

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks

Published on: August 4, 2018

15.3K
Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

78.6K

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Visual Perception

Background:

  • Mice are valuable models for studying behavior-neural activity relationships.
  • Mice can perform visual tasks like orientation discrimination and contrast detection.
  • The effect of stimulus contrast on mouse orientation discrimination is not fully understood.

Purpose of the Study:

  • To investigate how stimulus contrast impacts mouse performance in orientation discrimination tasks.
  • To compare performance across different task designs (2AFC and go/no-go).
  • To explore the underlying neural mechanisms in V1 related to contrast and orientation discrimination.

Main Methods:

  • Utilized two-alternative forced choice (2AFC) and go/no-go task designs.
  • Tested mouse performance in discriminating orthogonal orientations at varying stimulus contrasts.
  • Conducted physiological experiments in V1 (primary visual cortex) to measure neural responses.

Main Results:

  • Mouse performance in orientation discrimination increased with stimulus contrast.
  • Higher performance was observed at high contrast when stimuli had a single contrast level compared to multiple levels.
  • V1 neural discriminability of orientations also increased with contrast.
  • Neural discriminability at high contrast was superior in the single-contrast condition, linked to reduced response variance.

Conclusions:

  • Mouse orientation discrimination performance adapts to the contrast range of stimuli.
  • This adaptation is partly explained by the contrast-range dependent discriminative capacity of V1 neurons.
  • Findings highlight the interplay between stimulus statistics and neural processing in visual perception.