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Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases
A D Richards1, R Roberts, B M Dunn
1Department of Biochemistry, University of Wales College of Cardiff.
FEBS Letters
|April 10, 1989
Abstract:
Inhibitory constants (Ki) between 5 and 35 nM were derived (under different conditions of pH and ionic strength) for the interaction of HIV-1 proteinase with acetyl-pepstatin and H-261, two characteristic inhibitors of aspartic proteinases. Thus this enzyme, essential for replication of the AIDS virus, may be classified unequivocally as belonging to this proteinase family.