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Related Concept Videos

The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Energy Budgets00:51

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Organisms must balance energy intake with the energy required for growth, maintenance and reproduction. These trade-offs result in a variety of survivorship and reproductive strategies, including semelparity and iteroparity. Semelparous species, like annual plants, have only one reproductive episode in their lifetimes and consequently have short lifespans. Iteroparous species, by contrast, have many reproductive events during their lifetimes but have relatively few offspring. These two...
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Updated: Mar 31, 2026

Simultaneous Assessment of Cardiomyocyte DNA Synthesis and Ploidy: A Method to Assist Quantification of Cardiomyocyte Regeneration and Turnover
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Changes in Regenerative Capacity through Lifespan.

Maximina H Yun1

  • 1Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK. maximina.yun@ucl.ac.uk.

International Journal of Molecular Sciences
|October 30, 2015
PubMed
Summary
This summary is machine-generated.

Regenerative abilities decline with age due to intrinsic and extrinsic factors, impacting tissue health. Understanding these aging mechanisms is key to developing therapies for better tissue regeneration and extended healthspan.

Keywords:
agingaxolotlnewtplanariaregenerationreprogrammingsenescencestem cellszebrafish

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Area of Science:

  • Gerontology and Regenerative Medicine
  • Molecular and Cellular Biology

Background:

  • Organismal regenerative capacity changes across the lifespan.
  • Aging leads to decreased tissue homeostasis and regeneration, causing degeneration and pathology.
  • Both cell-intrinsic (e.g., cellular senescence) and cell-extrinsic factors contribute to this decline.

Purpose of the Study:

  • To review how regenerative abilities change throughout life.
  • To identify factors influencing age-related regenerative decline.
  • To explore therapeutic interventions for improving regeneration and healthspan.

Main Methods:

  • Literature review of mammalian regeneration models.
  • Analysis of models with age-independent regenerative abilities.
  • Synthesis of current understanding on regeneration and aging.

Main Results:

  • Regenerative decline is a common aging phenotype.
  • Cellular senescence and altered microenvironments are key mechanisms.
  • Comparative studies highlight potential strategies for enhancing regeneration.

Conclusions:

  • Understanding the interplay between aging and regeneration is crucial for therapeutic development.
  • Investigating organisms with sustained regenerative capacity offers valuable insights.
  • Targeting age-related mechanisms can improve tissue repair and extend healthspan.