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Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Related Experiment Video

Updated: Mar 31, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

An update on chemotherapy for osteosarcoma.

Stefano Ferrari¹, Massimo Serra²

¹a Musculoskeletal Oncology Department , Rizzoli Orthopaedic Institute , Via Pupilli 1, Bologna 40136 , Italy.

Expert Opinion on Pharmacotherapy

|October 30, 2015

Summary

This summary is machine-generated.

Chemotherapy has improved osteosarcoma survival, but innovations are slow. Personalized chemotherapy, based on pharmacogenetics, is the future for this rare bone cancer.

Keywords:

cisplatin doxorubicin ifosfamide methotrexate mifamurtide neoadjuvant chemotherapy osteosarcoma pharmacogenetics prognostic factors salvage chemotherapy tyrosine kinase inhibitors

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Last Updated: Mar 31, 2026

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

Oncology
Pharmacology
Genetics

Background:

Chemotherapy significantly improved osteosarcoma survival since the 1970s.
Recent years have yielded clinically and scientifically relevant insights into osteosarcoma treatment.

Purpose of the Study:

To review recent phase 2 and 3 study results in osteosarcoma.
To discuss insights supporting a personalized chemotherapy approach for osteosarcoma.

Main Methods:

Review of published data and international meeting presentations.
Focus on recent phase 2 and 3 clinical studies.
Specific analysis of studies on personalized chemotherapy.

Main Results:

The MAP (methotrexate, doxorubicin, cisplatin) regimen is the current standard of care.
Poor pathological response to primary chemotherapy predicts survival.
Genomic complexity hinders near-term molecularly targeted therapies.

Conclusions:

International collaboration is crucial for rare tumors like osteosarcoma.
Current evidence does not support altering post-operative treatment based on pathological response.
Personalizing chemotherapy using pharmacogenetics is the future research direction for osteosarcoma.