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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Early atherosclerosis in ulcerative colitis: cross-sectional case-control study.

Samit S Jain1, Dharmesh K Shah1, Pravir A Gambhire1

  • 1Department of Gastroenterology, Topiwala National Medical College and Bai Yamunabai Laxman Nair Hospital.

Journal of Digestive Diseases
|October 30, 2015
PubMed
Summary
This summary is machine-generated.

Ulcerative colitis patients show increased early atherosclerosis, indicated by higher carotid intima-media thickness (CIMT). This is linked to factors like age, disease duration, insulin resistance (HOMA-IR), and homocysteine levels.

Keywords:
atherosclerosiscarotid intima media thicknesshomocysteineinsulin resistanceulcerative colitis

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Area of Science:

  • Cardiovascular Science
  • Gastroenterology
  • Metabolic Research

Background:

  • Inflammatory bowel diseases like ulcerative colitis (UC) are associated with increased cardiovascular risk.
  • Subclinical atherosclerosis may be present in UC patients, necessitating early detection and management.

Purpose of the Study:

  • To assess subclinical atherosclerosis in UC patients using carotid intima-media thickness (CIMT).
  • To investigate correlations between CIMT, serum homocysteine, and homeostasis model assessment-insulin resistance (HOMA-IR) in UC.

Main Methods:

  • A comparative study involving 60 UC patients and 60 healthy controls, excluding individuals with known atherosclerosis risk factors.
  • Measurements included fasting blood glucose, lipid profile, HOMA-IR, erythrocyte sedimentation rate (ESR), serum vitamin B12, homocysteine, and CIMT via B-mode duplex imaging.

Main Results:

  • UC patients exhibited significantly higher CIMT, ESR, fasting insulin, HOMA-IR, and homocysteine levels compared to controls.
  • Significant positive correlations were found between CIMT and age, UC duration, HOMA-IR, and homocysteine.
  • Homocysteine and HOMA-IR showed independent associations with CIMT and UC duration, respectively.

Conclusions:

  • Elevated CIMT in UC patients suggests subclinical atherosclerosis.
  • Age, UC duration, HOMA-IR, and homocysteine levels are key factors contributing to increased CIMT in UC.