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Inhalable nanocomposite microparticles: preparation, characterization and factors affecting formulation.

Ibrahim Elsayed1,2, Mohamed Hassan Hany AbouGhaly1,3

  • 1a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo University , Cairo 11562 , Egypt Tel: +20 1149944306 ; Fax: +20 233058256 ;

Expert Opinion on Drug Delivery
|October 30, 2015
PubMed
Summary

Nanocomposite microparticles offer advanced pulmonary drug delivery. These carriers effectively deliver drugs to the lungs, showing superiority over traditional nanoparticles and microparticles for sustained release.

Keywords:
aerodynamic particle sizelung depositionnanocomposite microparticlesspray drying

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Area of Science:

  • Pharmaceutical Sciences
  • Biomaterials Engineering

Background:

  • Nanocomposite microparticles are intelligent carriers for pulmonary drug delivery, comprising drug-encapsulated nanoparticles within polysaccharide microstructures.
  • Their aerodynamic properties facilitate deep lung deposition, while nanoparticles resist clearance mechanisms for prolonged drug retention.

Purpose of the Study:

  • To explore the preparation and characteristics of nanocomposite microparticles for enhanced pulmonary drug delivery.
  • To investigate the factors influencing aerodynamic properties, nanoparticle release, and in vivo behavior.

Main Methods:

  • Preparation techniques include spray drying, spray freeze drying, spray drying fluidised bed granulation, and dry coating.
  • Optimization of excipients, preparation methods, and operational parameters are crucial for controlling particle characteristics and drug release.

Main Results:

  • Key parameters influencing particle properties include excipient selection, preparation technique, and operational settings.
  • In vivo studies can optimize carrier performance and track drug delivery through lung deposition and biological activity.

Conclusions:

  • Nanocomposite microparticles demonstrate superior performance compared to both nanoparticles and microparticles.
  • They represent a promising and effective carrier system for advanced pulmonary drug delivery applications.