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Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
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Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
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Gastric Emptying01:16

Gastric Emptying

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Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
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Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

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Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
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Related Experiment Video

Updated: Mar 31, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
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Decrease of serum total ghrelin in extensive atrophic gastritis: comparison with pepsinogens in histological

Suh Eun Bae1, Jeong Hoon Lee2, Young Soo Park3

  • 1a Health Screening and Promotion Center , University of Ulsan College of Medicine, Asan Medical Center , Seoul , South Korea .

Scandinavian Journal of Gastroenterology
|October 30, 2015
PubMed
Summary

Serum total ghrelin levels decrease with extensive gastric atrophy. While ghrelin shows potential as a biomarker, its diagnostic performance is less effective than pepsinogen I for detecting severe atrophic gastritis.

Keywords:
Atrophic gastritisHelicobacter pylorighrelin

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Biomarker Discovery

Background:

  • Ghrelin, a hormone primarily from the gastric oxyntic mucosa, is crucial for appetite regulation.
  • Chronic atrophic gastritis impairs ghrelin production, impacting its role in gastric health.
  • Understanding ghrelin's correlation with atrophy extent is vital for diagnostic advancements.

Purpose of the Study:

  • To evaluate the correlation between serum total ghrelin and the extent of atrophic gastritis.
  • To compare the efficacy of serum total ghrelin as a serologic marker against pepsinogen (PG).

Main Methods:

  • Histological assessment of atrophy in 154 patients using biopsies from antrum and corpus.
  • Measurement of fasting serum concentrations of total ghrelin and pepsinogens I and II.
  • Comparative analysis of serologic marker performance using receiver-operating characteristic (ROC) curves.

Main Results:

  • Serum total ghrelin significantly decreased in patients with extensive corpus greater curvature (CGC) atrophy.
  • Ghrelin levels correlated with pepsinogen I and the pepsinogen I/II ratio.
  • Serum total ghrelin demonstrated 57% sensitivity and 79% specificity for predicting extensive atrophy.

Conclusions:

  • Serum total ghrelin is reduced in extensive atrophic gastritis involving the CGC.
  • The diagnostic performance of serum total ghrelin is inferior to that of pepsinogen I.