Neonatal outcomes in twin pregnancies complicated by gestational diabetes compared with non-diabetic twins
M E Foeller1, S Zhao2, A Szabo2
1Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA.
Objective:
To compare neonatal outcomes of twin pregnancies with gestational diabetes (GDM) and preexisting diabetes with non-diabetic twin pregnancies.
Study Design:
US birth data from 2006 to 2009 was used to compare twin pregnancies of 16 562 GDM and 2137 preexisting diabetic with 258 857 non-diabetic twin gestations. Adjusted odds ratios (aORs) were calculated to assess effects of GDM and preexisting diabetes on neonatal outcomes.
Result:
Twin pregnancies with GDM vs non-diabetic twin pregnancies demonstrated decreased 5-min Apgar scores <4 (aOR 0.8, 95% confidence interval (CI) 0.68-0.94), fewer births before 32 weeks gestation (aOR 0.72, 95% CI 0.68-0.76), decreased birth weight less than the tenth percentile (aOR 0.84, 95% CI 0.81-0.89) and fifth percentile (aOR 0.85, 95% CI 0.81-0.89) and a trend toward lower rates of neonatal death (aOR 0.84, 95% CI 0.68-1.02).
Conclusion:
Certain adverse outcomes in pregnancies with GDM may be attenuated in twin gestations; however, further investigation is warranted.
More Related Videos
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Symptoms, Diagnosis, and Complications
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...


